Cervical Cancer begins in the lining of the cervix. Even though only about 12,800 cases of cervical cancer are diagnosed each year in the United States in women between the ages of 40 and 55, and about 4,600 women die each year from the disease, cancer of the cervix is the second to third most common cancer in women worldwide and is a leading cause of cancer-related death in women in underdeveloped countries.
Worldwide, approximately 500,000 cases of cervical cancer are diagnosed each year. Routine screening has decreased the incidence of invasive cervical cancer in the United States. Cervical cancer is more common in middle aged women and in women of poor socioeconomic status.
Most cervical cancers (80% to 90%) start where the ectocervix and the ectocervix meet and is called squamous cell carcinomas. Squamous cell carcinomas are composed of cells that resemble the flat, thin cells called squamous cells that cover the surface of the endocervix. The ectocervix is the part next to the vagina and the endocervix is the part of the cervix closest to the body of the uterus. The cervix is the lower part of the uterus (womb) and the upper part, or body, of the uterus, is where a fetus grows. The cervix connects the body of the uterus to the vagina (birth canal). Adenocarcinomas develops from the mucus-producing gland cells of the endocervix.
Almost all cervical cancers are caused by HPV (human papillomavirus). HPV is a common virus that is spread through sexual intercourse. Only certain strains of HPV actually lead to cervical cancer. Cervical cancer can spread to the bladder, intestines, lungs, and liver.
Risk factors for cervical cancer include having sex at an early age, multiple sexual partners, women whose mothers took the drug DES (diethylstilbestrol) during pregnancy in the early 1970s to prevent miscarriage, long-term use of birth control pills, weakened immune system, infections with genital herpes or chronic chlamydia infections and poor economic status (may not be able to afford regular Pap smears).
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